The use of array CGH (Comparative Genomic Hybridisation) is prescribed for patients with a normal karyotype and a clinical profile with:
Approximately 4% of births are children with intellectual disability. The array CGH has been recently introduced to identify chromosomal alternations in patients with pathological conditions, but without any alterations in the karyotype.
During this time, it has been revealed that this technology is more sensitive and efficient than the conventional karyotyping, as the solution of the array CGH is at least ten times higher than conventional karyotyping.
Bioarray has Cytoarray available, an array CGH that covers the complete genome with different resolutions of 60K, 180K and 400K.
Cytoarray and Cytoarray Plus are two array CGH specifically designed to detect intellectual disabilities caused by the loss (microdeletions) or gain (microduplications) of genetic material.
Cytoarray suggests a new clinical focus, as a suspicion of the syndrome that the child suffers from is not required. By applying traditional protocols, children and their parents have to go through months of endless tests (karyotyping, high-resolution karyotyping, subtelomeric bands, etc.)
When considering, at first, the higher capacity diagnostic test, we achieve the following: