In 2014 Bioarray pioneered the application of next generation sequencing (NGS) for Preimplantation Genetic Testing (termed PGS & PGD at the time). Bioarray firstly integrated informativity testing, monogenic-disease diagnosis and aneuploidy screening (i.e. PGT-M workup + PGT-M + PGT-A) in a single fast robust NGS workflow, providing unparalleled benefits to patients.
Now it is possible to use NGS technology for PGT allowing not only to select embryos with a higher probability of implantation and thus drastically improve the IVF success rates, but also to use it as a diagnostic tool for couples at higher risk of having children with genetic conditions.
Bioarray performs PGT with the three kinds of cells typically biopsied by IVF labs: polar bodies, day-3 embryo biopsy (blastomeres) and day-5 blastocyst biopsy (trophoectoderm). The latter allowing for mosaicism assessment thanks to NGS sensitivity.
Bioarray launched this new NGS testing after conducting an extensive validation study, based on the comparison of PGT-A results by NGS to well established aCGH, with more than 100 embryos diagnosed and 100% diagnosis correspondence by both techniques.
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